Edible vaccine, synonymously designated food vaccine, green vaccine, subunit vaccine, and plant-based vaccines, is an emerging trend in vaccinology since1990 (s). It has been considered a good biotechnological solution to help avoid the serious side effects, on animal and human health, encountered in traditional vaccines. In this context, the literature of review contains a plethora of reports addressing the past and the ongoing research pertaining to the development of numerous edible green vaccines against various infectious animal and human diseases. Infectious diseases are posing serious health threats to the life of both animal and human around the world. Vaccines are one of the strategies employed to prevent the spread of the infectious illnesses from a prophylactic side. The safety concern associated with the edible green vaccination has caught the interest of numerous researchers in laboratories all around the world. At the time being, edible green vaccines are being developed for human and veterinary purposes.  Additionally, this sort of vaccine has come under scrutiny due to the drastically lowered costs connected with the industrialization and marketing of edible green vaccines.  Before a vaccine is transferred from the lab to the medical market, it is customary for it to undergo extensive clinical studies.   Because of this, the majority of edible green vaccines discussed in various papers are still in the academic zone and haven’t moved into the industrial zone unless they can effectively overcome the clinical trials bottleneck.  We have gathered information in this minireview about the idea of edible green vaccines, transgenic food plants as renewable therapeutic factories, paradigms of edible green vaccines, current state, pros, cons, and future prospectives.