Al-Qadisiyah Journal of Veterinary Medicine Sciences
Official Journal of the College of Veterinary Medicine, University of Al-Qadisiyah

The correlation between the iron profile and some hematological values in dogs, Baghdad, Iraq

Document Type : Research Paper

Authors

Noor Abd Al-Kareem Qasim
Naseir Mohammed Badawi

Department of Internal and Preventive Veterinary Medicine, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.

https://doi.org/10.29079/qjvms.2023.184948
Abstract
Iron is the important element when deficient is associated with decrease blood values and animal which located under risk of many diseases. Complete Blood Counts (CBCs) was done by (VET haematology system). While the iron profile included serum iron, total iron binding capacity (TIBC) was measured by the colorimetric method. So, the canine ferritin was determined by the canine-FE ELISA kit. The unbound iron binding capacity (UIBC) and transferrin saturation (TS%) were calculated by equations. Pearson's correlation coefficient was used to measure the relationship between these test values. The correlation analysis of iron profile and haematological values was conducted on 175 dogs. The results showed that serum iron concentrations were positively and significantly correlated with TIBC, TS%, RBC, HGB, HCT, and platelet counts, whereas ferritin concentrations were negatively correlated only with MCV. Also, the results showed a negative correlation between ferritin and lymphocyte counts. The study concluded that serum iron levels are highly correlated with erythrogram values. Ferritin is limited in the diagnosis of iron deficiency anaemia because it acts as a biomarker and is not correlated with most erythrogram values. The negative correlation between ferritin and MCV reflected that MCV can be used in the estimation of iron deficiency
Crossmark
1. Coleman M. Iron metabolism. Hematol Clin Princ Appl. 2007;116-23.
2. McCown JL, Specht AJ. Iron homeostasis and disorders in dogs and cats: a review. J Am Anim Hosp Assoc. 2011;47(3):151-60. https://doi.org/10.5326/JAAHA-MS-5553
3. Harvey JW. Iron metabolism and its disorders. Clin Biochem Domest Anim. 2008;6:259-85. https://doi.org/10.1016/B978-0-12-370491-7.00009-X
4. Soubasis N, Rallis TS, Vlemmas J, Adamama-Moraitou KK, Roubies N, Prassinos NN, et al. Serum and liver iron concentration in dogs with experimentally induced hepatopathy. J Gastroenterol Hepatol. 2006;21(3):599-604. https://doi.org/10.1111/j.1440-1746.2005.04066.x
5. Weiss DJ. Iron and copper deficiencies and disorders of iron metabolism. Schalm's Vet Hematol. 2010;6:167-71.
6. Matur E, Ekiz EE, Erek M, Ergen E, Küçük SH, Erhan S, et al. Relationship between anemia, iron deficiency, and platelet production in dogs. 2019;75(6):351-4. https://doi.org/10.21521/mw.6233
7. Mitchell O, Feldman DM, Diakow M, Sigal SH. The pathophysiology of thrombocytopenia in chronic liver disease. Hepatic Med Evid Res. 2016;15(8):39-51. https://doi.org/10.2147/HMER.S74612
8. Li H, Ginzburg YZ. Crosstalk between iron metabolism and erythropoiesis. Adv Hematol. 2010;605435. https://doi.org/10.1155/2010/605435
9. Singh AK. Erythropoiesis: The Roles of Erythropoietin and Iron. In: Textbook of Nephro-Endocrinology. Elsevier; 2018. p. 207-15. https://doi.org/10.1016/B978-0-12-803247-3.00012-X
10. Paltrinieri S, Preatoni M, Rossi S. Microcytosis does not predict serum iron concentrations in anaemic dogs. Vet J. 2010;185(3):341-3. https://doi.org/10.1016/j.tvjl.2009.06.015
11. Betting A, Schweighauser A, Francey T. Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease. J Vet Intern Med. 2022;36(2):619-28. https://doi.org/10.1111/jvim.16367
12. Recalcati S, Invernizzi P, Arosio P, Cairo G. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun. 2008;30(1-2):84-9. https://doi.org/10.1016/j.jaut.2007.11.003
13. Yamashita M, Harada G, Matsumoto S, Aiba Y, Ichikawa A, Fujiki T, et al. Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin. Immunobiology. 2014;219(2):149-57. https://doi.org/10.1016/j.imbio.2013.08.011
14. Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol. 2017;29(9):401-9. https://doi.org/10.1093/intimm/dxx031
15. Van Vranken M. Evaluation of microcytosis. Am Fam Physician. 2010;82(9):1117-22.

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