Al-Qadisiyah Journal of Veterinary Medicine Sciences
Official Journal of the College of Veterinary Medicine, University of Al-Qadisiyah

Evaluation of Recombinant Ferritin of Echinococcus granulosus in Liver and Lung of Experimentally Infected Mice by Histopathological

Document Type : Research Paper

Authors

Noor Idan Jarad 1
Doaa Sabri Resen 2

1 Department of Microbiology /parasitology /college of Veterinary Medicine /Al Qadysah University

2 Department of veterinary microbiology / Al Qadisiyah university/Diwaniyah city

https://doi.org/10.29079/qjvms.2025.166725.1138
Abstract
The study aimed to evaluate recombinant ferritin of Echinococcus granulosus by histopathological study. The mice vaccinated subcutaneous with rEgferritin 50µg, then challenged intraperitoneal with viable protoscolices of E. granulosus isolated from hydatid cysts infected sheep. The cysts varied in size and number, with common occurrences in the liver and lungs.   In post- challenge infection, the vaccinated group revealed fewer and smaller cysts compared to the positive control group. The histopathological changes in internal organs such as (liver and lung) of a vaccinated group in Liver: showed inflammatory cell aggregations (immature granuloma) primarily consisting of lymphocytes and macrophages. Congestion of central veins. Presence of hepatic cords and proliferation of Kupffer cells in the hepatic tissue. Lung: Few inflammatory infiltrate, congestion blood vessels. Bronchioles showed with normal tissue lined by normal columnar epithelium. In contrast with the positive control group infected with E. granulosus protoscolices, which indicated that recombinant ferritin of Echinococcus granulosus has shown potential to modify these histopathological findings by enhancing immune responses.

Keywords

Hydatid cyst
histopathological changes
ferritin
liver and lung
Crossmark
Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 25, Issue 1
May 2026
Pages 45-51

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