Al-Qadisiyah Journal of Veterinary Medicine Sciences

Influence of a Second Dose of Ketamine-Xylazine Mixture on Hematological and Biochemical Profiles in Canine Anesthesia

Document Type : Research Paper

Authors

1 Department of Medicine and Surgery, College of Veterinary Medicine, University of Duhok, Iraq

2 Department of Theriogenology, Anatomy, and Physiology, College of Veterinary Medicine, University of Duhok, Iraq

10.29079/qjvms.2025.156449.1059

Abstract

Combination of ketamine and xylazine used as anesthetic agents in veterinary practice in developing countries and even in rural areas in developed countries. This protocol provides anesthesia for approximately 30 minutes, often necessitating a second dose for extended procedures. Study aimed to investigate the effects of administering a second dose of ketamine and xylazine on biochemical and hematological parameters in dogs. An experimental, randomized, crossover study. Twelve mongrel dogs of both sexes were used in this study, their body weights ranged from (16-25kg) kg with an average of (18.83kg) and the ages were between 6 and 18 months. Each dog was administered by two doses of ketamine and xylazine. Blood samples were collected before the first dose (S1), 30 minutes after the first dose (S2), 30 minutes after the second dose (S3), and 24 hours after the first dose (S4). The results show significant changes in several biochemical (lactate dehydrogenase P-value 0.000 and glucose P-value 0.001) and hematological (white blood cell P-value 0.067 and platelets P-value 0.058) parameters. While most other hematological and biochemical parameters show no significant differences before, during and after anesthesia. The administration of a second dose of ketamine and xylazine should be judiciously determined through a rigorous risk-benefit analysis. It is advisable to utilize a second dose only when necessary to complete a procedure, as significant biochemical and hematological changes were observed in our study. Other ways it should be avoided.

Keywords

References
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Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 24, Issue 1
January 2025
Pages 122-126
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