Document Type : Research Paper
Authors
1 Ministry of Agriculture, Iraq.
2 College of Veterinary Medicine, University of Basrah, Iraq
Abstract
Most the Liver affections detected at a late stage for anemic K9 (police dogs) and they are very important to estimate liver functions to disclose diseases.To study liver function in dogs, chose forty five K9 dogs from Basrah and Maysan province- south of Iraq, the first group of thirty five dogs affected with anemia and second group of ten dogs appeared clinically normal served as control. The clinical findings and blood parameters directed for anemia detection then serum levels of liver functions were estimated. The anemic dogs displayed pale mucous membranes, depression, dehydration, loss of appetite, lethargy, and weakness, moreover, tachycardia was evinced. The hematological parameters in anemic dogs revealed decreased in total RBCc, Hb and PCV, as well as reduction of MCV and MCHC in concerning microcytic hypochromic anemia (P<0.05).The differences of activity of liver functions between anemic and normal dogs were reported, in the anemic group was increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and bilirubin levels with significant importance than normal group (P<0.05). Other indicators included lowering levels of total protein and albumin in anemic dogs which were also significant (P<0.05). Anemic dogs showed changes in liver functions which are characterized by increased levels of ALT, AST, ALP, and bilirubin as well as decreased protein and albumin than normal, and associated signs of pale mucous membranes, depression, anorexia, and lethargy
Keywords
2. Zachary JF, McGavin MD. Pathologic Basis of Veterinary Disease. 5th ed. 2012. Elsevier Health Sciences. 1322 p.
3. Ettinger SJ, Feldman EC, Cote E. Textbook of Veterinary Internal Medicine. 8th ed. 2017. Elsevier Health Sciences. 2736 p.
4. Maxie G. Jubb, Kennedy & Palmer's Pathology of Domestic Animals. 2015. 2nd ed. Elsevier Health Sciences.
5. Bexfield N, Watson P. Diagnosis of canine liver disease. Inpractice. 2006;28(8):444.https://doi.org/10.1136/inpract.28.8.444
6. Dunlop RH, Malbert C-H. Veterinary pathophysiology. 1st ed. 2004. Blackwell. Iowa, USA. 350 p.
7. Center SA, ManWarren T, Slater MR, Wilentz E. Evaluation of twelve-hour preprandial and two-hour postprandial serum bile acids concentrations for diagnosis of hepatobiliary disease in dogs. J Am Vet Med Assoc. 1991;199(2):217-226.https://doi.org/10.2460/javma.1991.199.02.217
8. MacPhail CM, Lappin MR, Meyer DJ, Smith SG, Webster CR, Armstrong PJ. Hepatocellular toxicosis associated with administration of carprofen in 21 dogs. J Am Vet Med Assoc. 1998;212(12):1895-1901.https://doi.org/10.2460/javma.1998.212.12.1895
9. Kerr M. Veterinary Laboratory Medicine-Clinical biochemistry and hematology. 2nd ed. 2002. Blackwell Science Ltd. 368 p.https://doi.org/10.1002/9780470690246
10. Feldman BF, Zinkl JG, Jain NC. Schalm's veterinary hematology. 5th ed. 2000. Lippincott Williams and Wilkins. London. 1850 p.
11. Knottenbelt CM. Investigation of anaemia in dogs. Inpractice. 2001;23(6):306.https://doi.org/10.1136/inpract.23.6.306
12. Yu IB, Huang H. Prevalence and Prognosis of Anemia in Dogs with Degenerative Mitral Valve Disease. Biomed Res Int. 2016.https://doi.org/10.1155/2016/4727054
13. Elhiblu MA, Dua K, Mohindroo J, Mahajan SK, Sood NK, Dhaliwal PS. Clinico-hemato-biochemical profile of dogs with liver cirrhosis. Vet World. 2015;8(4):487-491.https://doi.org/10.14202/vetworld.2015.487-491
14. Feldman BF, Kaneko JJ, Farver TB. Anemia of inflammatory disease in the dog: clinical characterization. Am J Vet Res. 1981;42(7):1109-1113.
15. Radakovich LB, Pannone SC, Truelove MP, Olver CS, Santangelo KS. Hematology and biochemistry of aging-evidence of "anemia of the elderly" in old dogs. Vet Clin Pathol. 2017;46(1):34-45.https://doi.org/10.1111/vcp.12459
16. Cunningham JG. Textbook of veterinary physiology. 3rd ed. 2002. Sanders, USA. 575 p.
17. Harvey JW. Atlas of veterinary hematology. 2001. W.O. Saunders Company.
18. McCown JL, Specht AJ. Iron homeostasis and disorders in dogs and cats: a review. J Am Anim Hosp Assoc. 2011;47(3):151-160.https://doi.org/10.5326/JAAHA-MS-5553
19. Weiss DJ, Wardrop KJ. Schalm's Veterinary Hematology. 2010. Blackwell Publishing. Ames, Iowa.
20. Thrall MA, Weiser G, Allison RW, Campbell TW. Veterinary Hematology and Clinical Chemistry. 2nd ed. 2012. John Wiley & Sons, Inc. 762 p.
21. Webb CB, Twedt DC, Meyer DJ. Copper-associated liver disease in Dalmatians: a review of 10 dogs (1998-2001). J Vet Intern Med. 2002;16(6):665-668.https://doi.org/10.1111/j.1939-1676.2002.tb02405.x
22. Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53(3):250.
23. Adamama-Moraitou KK, Rallis TS, Papazoglou LG, Papasteriadis A, Roubies N, Kaldrimidou H, et al. Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency. Can J Vet Res. 2004;68(1):56-61.