Document Type : Research Paper

Authors

1 University of AL-Qadisiyah College of Veterinary Medicine, Veterinary Obstetrics

2 Department of Public Health, College of Veterinary Medicine, University of Al-Qadisiyah, Diwaniyah, Iraq

10.29079/qjvms.2025.158481.1077

Abstract

Abstract   In the present study, used 20 females white rats divided into two groups. Therefore total animals, of age 105 - 110 days. Initially the study animals were weighed and the groups marked; T & C. The treatment group(T) was administered with 40 milligrams/kg of the alcoholic extract bee propolis  daily drenching  for 30 days and the control group (C) was denied dose. Lastly, weight gained and weight of newborns were analyzed as part of the study at the end of the project. The findings of the present investigation revealed a highly significant difference in the rate of weight gain in favour of the treatment group (T) as compared to control group of animals (C), 57. 31 and 27. 3gm. respectively. The results however failed to reveal any statistical changes in the weight of newborns in both groups of the study 23. 50 and 26. 250gm. respectively. The results of weight of newborn rats which were dosed with the alcoholic extract of the bee propolis is less when compared to the weight of the newborn rats that were not dosed with the alcoholic extract of bee propolis.

Keywords

1- Fokt H, Pereira A, Ferreira A, Cunha A, Aguiar C. How do bees prevent hive infections? The antimicrobial properties of propolis. Current research, technology and education topics in applied microbiology and microbial biotechnology. 2010;1:481-93.
2- Sabir A. Prospect of using propolis in conservative dentistry and endodontic treatment (basic research vs clinical application): prospek penggunaan propolis dalam bidang operative dentistry dan perawatan endodonti (penelitian dasar vs aplikasi klinis. Dentika: Dental Journal. 2014;18(2):185-9. https://doi.org/10.32734/dentika.v18i2.2028
3- Sforcin JM. Biological properties and therapeutic applications of propolis. Phytotherapy research. 2016;30(6):894-905. https://doi.org/10.1002/ptr.5605
4- Parolia A, Thomas MS, Kundabala M, Mohan M. Propolis and its potential uses in oral health. International Journal of Medicine and Medical Science. 2010;2(7):210-5.
5- Toreti VC, Sato HH, Pastore GM, Park YK. Recent progress of propolis for its biological and chemical compositions and its botanical origin. Evidence‐Based Complementary and Alternative Medicine. 2013;(1):697390. https://doi.org/10.1155/2013/697390
6- Wagh VD. Propolis: a wonder bees product and its pharmacological potentials. Advances in Pharmacological and Pharmaceutical Sciences. 2013;(1):308249.
https://doi.org/10.1155/2013/308249
7- Ciftci-Yilmaz S, Azman ZN, Kosem K, Gunduz E, Grenman R. Evaluating antioxidant capacity of different propolis samples from konya, Turkey and their inhibitory effect on head and neck cancer cells. BioRxiv. 2017:183913. https://doi.org/10.1101/183913
8- Zheng YZ, Deng G, Liang Q, Chen DF, Guo R, Lai RC. Antioxidant activity of quercetin and its glucosides from propolis: A theoretical study. Scientific reports. 2017;7(1):7543. https://doi.org/10.1038/s41598-017-08024-8
9- Sforcin JM. Propolis and the immune system: a review. Journal of ethnopharmacology. 2007;113(1):1-4. https://doi.org/10.1016/j.jep.2007.05.012
10- Abdulrhman M, Samir Elbarbary N, Ahmed Amin D, Saeid Ebrahim R. Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatric hematology and oncology. 2012;29(3):285-92. https://doi.org/10.3109/08880018.2012.669026
11- Ahmed R, Tanvir EM, Hossen MS, Afroz R, Ahmmed I, Rumpa NE, Paul S, Gan SH, Sulaiman SA, Khalil MI. Antioxidant properties and cardioprotective mechanism of Malaysian propolis in rats. Evidence‐BasedComplementary and Alternative Medicine. 2017;(1):5370545. https://doi.org/10.1155/2017/5370545
12- Sung SH, Choi GH, Lee NW, Shin BC. External Use of Propolis for Oral, Skin, and Genital Diseases: A Systematic Review and Meta‐Analysis. Evidence‐Based Complementary and Alternative Medicine. 2017;(1):8025752.Based Complement. Alternat. Med. https://doi.org/10.1155/2017/8025752
13- Kuropatnicki AK, Szliszka E, Krol W. Historical aspects of propolis research in modern times. Evid Based Complement Alternat Med. 2013. https://doi.org/10.1155/2013/964149
14- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochir Pol. 2017;14:43. https://doi.org/10.5114/kitp.2017.66929
15- Alonso-Salces RM, Cugnata NM, Guaspari E, Pellegrini MC, Aubone I, De Piano FG, et al. Natural strategies for the control of Paenibacillus larvae, the causative agent of American foulbrood in honey bees: a review. Apidologie. 2017:1-14. https://doi.org/10.1007/s13592-016-0483-1
16- Rufatto LC, Dos Santos DA, Marinho F, Henriques JAP, Ely MR, Moura S. Red propolis: chemical composition and pharmacological activity. Asian Pac J Trop Biomed. 2017.
https://doi.org/10.1016/j.apjtb.2017.06.009
17- Kasiotis KM, Anastasiadou P, Papadopoulos A, Machera K. Revisiting Greek Propolis: chromatographic analysis and antioxidant activity study. PLoS One. 2017;12:e0170077. https://doi.org/10.1371/journal.pone.0170077
18- Omar R, Igoli JO, Zhang T, Gray AI, Ebiloma GU, Clements CJ, et al. The chemical characterization of Nigerian propolis samples and their activity against Trypanosoma brucei. Sci Rep. 2017;7:923.
https://doi.org/10.1038/s41598-017-01038-2
19- Simone-Finstrom M, Borba RS, Wilson M, Spivak M. Propolis counteracts some threats to honey bee health. Insects. 2017;8:46.
https://doi.org/10.3390/insects8020046
20- Drescher N, Klein AM, Neumann P, Yañez O, Leonhardt SD. Inside honeybee hives: impact of natural propolis on the ectoparasitic mite Varroa destructor and viruses. Insects. 2017;8:15. https://doi.org/10.3390/insects8010015
21- Afrouzan H, Zakeri S, Mehrizi AA, Molasalehi S, Tahghighi A, Shokrgozar MA, et al. Anti-plasmodial assessment of four different Iranian propolis extracts. Arch Iran Med. 2017;20.
22- Rajpara S, Wilkinson MS, King CM, Gawkrodger DJ, English JS, Statham BN, et al. The importance of propolis in patch testing: a multicentre survey. Contact Dermatitis. 2009;61:287-90. https://doi.org/10.1111/j.1600-0536.2009.01629.x
23- Pasupuleti VR, Sammugam L, Ramesh N, Gan SH. Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev. 2017. https://doi.org/10.1155/2017/1259510
24- Bogdanov S. Functional and biological properties of bee products. Bee Product Sci. 2011:1-12. Available from: www.bee-hexagon.net.
25- Arabameri A, Sameni H, Bandegi A. The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress. Int J Reprod BioMed. 2011;15(8):509-20. https://doi.org/10.29252/ijrm.15.8.509
26- Seo KW, Park M, Song YJ, Kim S, Yoon KR. The protective effects of propolis on hepatic injury and its mechanism. Phytother Res. 2003;17(3):250-3. https://doi.org/10.1002/ptr.1120
27- Deshmuk S, Borle M. Studies on the insecticidal properties of indigenous plant products. J Ethnopharmacol. 1995;37:11-8.
28- Petrie A, Watson P. Statistics of veterinary and animal science. 3rd ed. Wiley-Blackwell; 2013.
29- Abbass A, El-Asely A, Kandiel M. Effects of dietary propolis and pollen on growth performance, fecundity, and some hematological parameters of Oreochromis niloticus. Turk J Fish Aquat Sci. 2012;12:851-9.
30- Yousef MI, Kamel KI, Hassan MS, El-Morsy AM. Protective role of propolis against reproductive toxicity of triphenyltin in male rabbits. Food Chem Toxicol. 2010;48:1846-