Document Type : Review Paper

Authors

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

10.29079/qjvms.2023.183460

Abstract

This work was aimed to highlight on the pharmacological role of propolis in management of different disorders. Propolis defined as (bee glue) is common surname which submit to substance of resinous accumulate through diverse forms of plants by means of bees, the phrase of propolis appearance by Greek refer on security (pro) and settlement, population for “polis”, the bee cell, as new terms. Chemically constituents for it depends on derivation through its bees accumulate foodstuff. Bee glue and it extracts have several medicinal apply, in the arrangement of several healthiness problem due to its effects, prevent the inflammation and oxidative stress, destruction of bacterial and fungi, prevent of ulcer, prevent of cancer, antiseptics, and have strengthens immune system. It is unusual biological behaviors, example anticancer, antiviral, antibacterial, and antihypertensive effect. Bee glue include important substances as flavonoids which responsible mainly on biological activity of propolis. The amount of flavonoid which present in bee glue will determine the quality of it, so the number of flavonoids present in bee glue will be standard for estimate the value of bee glue. It is characterized by biological consequence like prevent the inflammation, prevent the infection with bacteria in addition to prevent disease caused by virus. Propolis is a unique natural remedy, possesses a wide range of pharmacological effects. Propolis has served as a rich source in the different actively constituents especially phenolic compounds so it has potential for treatment in various acute and chronic human diseases.

Keywords

1. Wagh VD. Propolis: A Wonder Bees Product and Its Pharmacological Potentials. Adv Pharmacol Sci. 2013:308249.https://doi.org/10.1155/2013/308249
2. Ugur A, Arslan T. An in vitro study on antimicrobial activity of propolis from mugla province of Turkey. J Med Food. 2004;7(1):90.https://doi.org/10.1089/109662004322984761
3. Shehu A, Ismail S, Rohin MK, Harun A, Aziz AA, Haque M. Antifungal properties of Malaysian Tualang honey and stingless bee propolis against Candida albicans and Cryptococcus neoformans. J Appl Pharm Sci. 2016;6(2):44-50.https://doi.org/10.7324/JAPS.2016.60206
4. Maruyama H, Sumitou Y, Sakamoto T, Araki Y, Hara H. Antihypertensive effects of flavonoids isolated from Brazilian green propolis in spontaneously hypertensive rats. Biol Pharm Bull. 2009;32(7):1244-50.https://doi.org/10.1248/bpb.32.1244
5. Prytzyk E, Dantas AP, Salomao K, Pereira AS, Bankova VS, Castro SL. Flavonoids and trypanocidal activity of Bulgarian propolis. J Ethnopharmacol. 2003;88:189-193.https://doi.org/10.1016/S0378-8741(03)00210-1
6. Przybyłek I, Karpiński TM. Antibacterial properties of propolis. Molecules. 2019;24:2047.https://doi.org/10.3390/molecules24112047
7. Lotti C, Fernandez MC, Piccinelli AL, Cuesta-Rubio O, Hernandez IM, Rastrelli L. Chemical constituents of red Mexican propolis. J Agric Food Chem. 2010;58:2209-2213.https://doi.org/10.1021/jf100070w
8. Biluca FC, Braghini F, Gonzaga LV, Costa ACO, Fett R. Physicochemical profiles, minerals, and bioactive compounds of stingless bee honey (Meliponinae). J Food Compos Anal. 2016;50:61-69.https://doi.org/10.1016/j.jfca.2016.05.007
9. Pietta PG, Gardana C, Pietta AM. Analytical methods for quality control of propolis. Fitoterapia. 2002;73(1):7-20.https://doi.org/10.1016/S0367-326X(02)00186-7
10. Rao PV, Krishnan KT, Salleh N, Gan SH. Biological and therapeutic effects of honey produced by honey bees and stingless bees: A comparative review. Rev Bras Farmacogn. 2016;26:657-664.https://doi.org/10.1016/j.bjp.2016.01.012
11. Hayriye ALP. Effects of propolis on the immune system. Anadolu J AARI. 2018;28(2):99-104.
12. Bankova V, Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000;31:3-15.https://doi.org/10.1051/apido:2000102
13. Andrea B. Evidence on the health benefits of supplemental propolis. Nutrients. 2019;11(11):2705.https://doi.org/10.3390/nu11112705
14. Nolkemper S, Reichling J, Sensch KH, Schnitzler P. Mechanism of herpes simplex virus type 2 suppression by propolis extracts. Phytomedicine. 2010;17(2):132-138.https://doi.org/10.1016/j.phymed.2009.07.006
15. Popova MP, Chinou IB, Marekov IN, Bankova VS. Terpenes with antimicrobial activity from Cretan propolis. Phytochemistry. 2009;70(10):1262-1271.https://doi.org/10.1016/j.phytochem.2009.07.025
16. Bonamigo T, Campos JF, Alfredo TM, Balestieri JBP, Cardoso CAL, Paredes-Gamero EJ, de Picoli Souza K, dos Santos EL. Antioxidant, cytotoxic, and toxic activities of propolis from two native bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. Oxid Med Cell Longev. 2017:1038153.https://doi.org/10.1155/2017/1038153
17. Batista LLV, Campesatto EA, Assis MLB, Barbosa APF, Grillo LAM, Dornelas CB. Comparative study of topical green and red propolis in the repair of wounds induced in rats. Rev Col Bras Cir. 2012;39:515-520.https://doi.org/10.1590/S0100-69912012000600012
18. Elumalai P, Muninathan N, Megalatha ST, Suresh A, Kumar KS, Jhansi N, Kalaivani K, Krishnamoorthy G. An insight into anticancer effect of propolis and its constituents: a review of molecular mechanisms. Evid Based Complement Alternat Med. 2022.https://doi.org/10.1155/2022/5901191
19. Almeida EC, Menezes H. Anti-inflammatory activity of propolis extracts: a review. J Venom Anim Toxins. 2002;8:191-212.https://doi.org/10.1590/S0104-79302002000200002
20. Li CL, Yue-Wen C, Cheng-Chum C. Antibacterial and DPPH free radical scavenging activities of the ethanol extract of propolis collected in Taiwan. J Food Drug Anal. 2003;11(4):277-282.
21. Kothail S, Jayanthi B. Environmental Impact on Stingless bee propolis (Tetragonula iridipennis) reared from Two Different Regions of Tamilnadu- A comparative Study. Int J Chemtech Res. 2015;7(7):3081-3088.
22. Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36(4):347-363.https://doi.org/10.1016/S0278-6915(97)00145-2
23. Foket H, Pereira A, Ferreira AM, Cunha A, Aguiar C. How do bees prevent hive infections? The antimicrobial properties of propolis. Curr Res Technol Educ Top Appl Microbiol Microb Biotechnol. 2010;1:481-493.
24. Volpert R, Arslan T. Biochemical activities of propolis extracts. Photodynamic activities. Zeitschrift für Naturforsch. 1993;48:858-62.https://doi.org/10.1515/znc-1993-11-1207
25. Nakajima Y, Tsuruma K, Shimazawa M, Mishima S, Hara H. Comparison of bee products based on assays of antioxidant capacities. BMC Complement Altern Med. 2009;9:4.https://doi.org/10.1186/1472-6882-9-4
26. Carvalho AA, Finger D, Machado CS, Schmidt EM, Costa PM, Alves APNN. In vivo antitumoral activity and composition of an oil extract of Brazilian propolis. Food Chem. 2011;126:1239-1245.https://doi.org/10.1016/j.foodchem.2010.12.035
27. Farre R, Frasquest I, Sanchez A. Propolis and human health. Pharm. 2004;45:21-43.
28. Orsolic N, Basic I. Immunomodulation by water-soluble derivative of propolis: a factor of antitumor reactivity. J Ethnopharmacol. 2003;84:265-273.https://doi.org/10.1016/S0378-8741(02)00329-X
29. Liviu AL, Marghitas DS, Dezmirean OB. Important developments in Romanian propolis research. Evid Based Complement Alternat Med. 2013.https://doi.org/10.1155/2013/159392
30. De la Rosa LA, Alvarez-Parrilla E, Gonzalez-Aguilar GA. Fruit and vegetable phytochemicals: chemistry, nutritional value, and stability. 1st edition. Wiley Blackwell; 2010.https://doi.org/10.1002/9780813809397
31. Zhang C, Huang S, Wei W, Ping S, Shen X, Li Y, Hu F. Development of high-performance liquid chromatographic for quality and authenticity control of Chinese propolis. J Food Sci. 2014;79:C1315-C1322.https://doi.org/10.1111/1750-3841.12510
32. Gardana C, Scaglioni M, Pietta P, Simonetti P. Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007;45(3):390-399.https://doi.org/10.1016/j.jpba.2007.06.022
33. Shuai H, Cui-Ping Z, Kai W, George QL, Fu-Liang H. Recent advances in the chemical composition of propolis. Molecules. 2014;19:19610-19632.https://doi.org/10.3390/molecules191219610
34. Bueno-Silva B, Alencar SM, Koo H, Ikegaki M, Silva GV, Napimoga MH. Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis. J Agric Food Chem. 2013;61:4546-4550.https://doi.org/10.1021/jf305468f
 
35. Cavendish RL, Santos JDS, Neto RB, Paixão AO, Oliveira JV, de Araujo ED, Berretta E, Silva AA, Thomazzi SM, Cardoso JC, Gomes MZ. Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. J Ethnopharmacol. 2015;173:127-133.https://doi.org/10.1016/j.jep.2015.07.022
36. Hegazi AG, El Hady FKA. Egyptian propolis: 3. Antioxidant, antimicrobial activities and chemical composition of propolis from reclaimed lands. Zeitschrift für Naturforsch. 2002;57:395-402.https://doi.org/10.1515/znc-2002-3-432
37. Cvek J, Medić-Šarić M, Vitali D, Vedrina-Dragojević I, Smit Z, Tomić S. The content of essential and toxic elements in Croatian propolis samples and their tinctures. J Apic Res. 2008;47(1):35-45.https://doi.org/10.1080/00218839.2008.11101421
38. Miguel MG, Nunes S, Dandlen SA, Cavaco AM, Antunes MD. Phenols and antioxidant activity of hydro-alcoholic extracts of Propolis from Algarve, south of Portugal. Food Chem Toxicol. 2010;48:3418-3423.https://doi.org/10.1016/j.fct.2010.09.014
39. Mani F, Damasceno HCR, Noveli ELB, Martins EAM, Sforcin JM. Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables. J Ethnopharmacol. 2006;105:95-98.https://doi.org/10.1016/j.jep.2005.10.011
40. Cvek J, Medić-Šarić M, Vitali D, Vedrina-Dragojević I, Šmit Z, Tomić S. The content of essential and toxic elements in Croatian propolis samples and their tinctures. J Apic Res. 2008;47(1):35-45.https://doi.org/10.1080/00218839.2008.11101421
41. Banskota TY, Adnyana K, Ishii E, Midorikawa K, Matsushige K, Kadota S. Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis. Phytomedicine. 2001;8(1):16-32.https://doi.org/10.1078/0944-7113-00004
42. Dubtsovae A, Iazebnic B, Kas'yanenko VI, Komissarenko IA. Eradication of H. pylori may be with 30% water extract of propolis. Helicobacter. 2009;14(4):405.
43. Wang KEA. Polyphenol-rich propolis extracts strengthen intestinal barrier function by activating AMPK and ERK signaling. Nutrients. 2016;8:272.https://doi.org/10.3390/nu8050272
44. Seo KW, Park M, Song YJ, Kim SJ, Yoon KR. The protective effects of propolis on hepatic injury and its mechanism. Phytother Res. 2003;17:250.https://doi.org/10.1002/ptr.1120
45. Bhadauria M. Propolis prevents hepatorenal injury induced by chronic exposure to carbon tetrachloride. Evid Based Complement Alternat Med. 2012;2012:12 pages. Article ID 235358.https://doi.org/10.1155/2012/235358
46. Ayes NK, Sibel S, Fatma M, Osman S. Antifungal activity of propolis in four different fruit juices. Food Technol Biotechnol. 2007;45(1):57-61.
47. Koc AN, Silici S, Kasap F, Hormet-Oz HT, Mavus-Buldu H, Ercal B. Antifungal activity of the honeybee products against Candida spp. and Trichosporon spp. J Med Food. 2011;14(1-2):128-134.https://doi.org/10.1089/jmf.2009.0296
48. Gutierrez HE. Activated antimicrobial and chemical profile of propolis Mexicanos sobre cepas de Pasteurella multocida aisladas de conejos. Thesis. Universidad Nacional Autonoma de Mexico. 2011.
49. Bogdanov S. Propolis composition, health, medicine: A review. Bee Product Science. 2012.
50. Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev. 2007;65(2):S140-S146.https://doi.org/10.1111/j.1753-4887.2007.tb00352.x
51. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al. Diabetes control and complications trial/epidemiology of diabetes interventions and complications (DCCT/EDIC) study group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353(25):2643-53.https://doi.org/10.1056/NEJMoa052187
52. Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease. Primary Care. 2013;40(1):195-211.https://doi.org/10.1016/j.pop.2012.11.003
53. Amin KA, Ahmed RR, Hozayen WG, Attat A. Renoprotective and antioxidant effect of Silymarin and propolis on diclofenac sodium induced renal toxicity in rats. Int J Pure Appl Biosci. 2017;5(2):31-42.https://doi.org/10.18782/2320-7051.2421
54. Brizzi MF, Formato L, Bonamini R. The molecular mechanisms of angiogenesis: a new approach to cardiovascular disease. Ital Heart J. 2001;2(2):81-92.
55. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32(9):2045-2051.https://doi.org/10.1161/ATVBAHA.108.179705
56. Ahn MR, Kunimasa K, Ohta T. Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Lett. 2007;252(2):235-243.https://doi.org/10.1016/j.canlet.2006.12.039
57. Wang D, De-Bing X, Yu-Jun H, Zeng-Peng L, Xiao-Hua W, Jiang-Hong M. Effect of caffeic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro. World J Gastroenterol. 2005;11(26):4008-4012.https://doi.org/10.3748/wjg.v11.i26.4008
58. Kim JD, Liu L, Guo W, Meydani M. Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem. 2006;17:165-176.https://doi.org/10.1016/j.jnutbio.2005.06.006
59. Berretta MAD, Capcha JMC, Jong DD. Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease. Biomed Pharmacother. 2020;131:110622.https://doi.org/10.1016/j.biopha.2020.110622
60. Chakravarti A, Kumaria R. Circulating levels of tumor necrosis factor-α and interferon- γ in patients with dengue and dengue hemorrhagic fever during an outbreak. Indian J Med Res. 2006;123:25-30.
61. Catchpole O, Mitchell K, Bloor S, Davis P, Suddes A. Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells. Fitoterapia. 2015;106:167-174.https://doi.org/10.1016/j.fitote.2015.09.004
62. Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs? J Ethnopharmacol. 2011;133:253-60.https://doi.org/10.1016/j.jep.2010.10.032
63. Aisha AFA, Abu-salah KM, Alrokayan SA, Ismail Z, Majid AMSA. Evaluation of antiangiogenic and antioxidant properties of Parkia speciosa Hassk extract. Pak J Pharm Sci. 2012;25(1):7-14.
64. Tekiner OY, Yeşilkaya B. The Effects of Propolis on Human Health. BeeStudies. 2021;13(1):1721.https://doi.org/10.51458/BSTD.2021.13
65. Bueno-Silva B, Marsola A, Ikegaki M, Alencar SM, Rosalen PL. The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. Nat Prod Res. 2017;31(11).https://doi.org/10.1080/14786419.2016.1239088
66. Chen TG, Lee JJ, Lin KH, Shen CH, Chou DS, Sheu JR. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol. 2007;50(3):121-126.
67. Olczyk K, Wisowski G, Mencner L, Stojko J, Kozma EM. Propolis modulates fibronectin expression in the matrix of thermal injury. Biomed Res Int. 2014;2014:748101.https://doi.org/10.1155/2014/748101
68. Henshaw FR, Bolton T, Nube V. Topical application of the bee hive protectant propolis is well tolerated and improves human diabetic foot ulcer healing in a prospective feasibility study. J Diabetes Complications. 2014;28(6):850-857.https://doi.org/10.1016/j.jdiacomp.2014.07.012
69. Orsolic N, Bevanda M, Bendelja K, Horvat K, Benkovic V, Basic I. Propolis and related polyphenolic compounds: their relevance on host resistance and interaction with chemotherapy. J Ethnopharmacol. 2008;133:253-60.
70. Scazzocchioa A, Alessandrinia D, Pantanellab F. Multifactorial aspects of antimicrobial activity of propolis. Microbiol Res. 2006;161:327-333.https://doi.org/10.1016/j.micres.2005.12.003
71. Walgrave SE, Warshaw EM, Glesne LA. Allergic contact dermatitis from propolis. Dermatitis. 2005;16:209-215.https://doi.org/10.1097/01206501-200512000-00004
72. Hsu CY, Chiang WC, Weng TI, Chen WJ, Yuan A. Laryngeal edema and anaphylactic shock after topical propolis use for acute pharyngitis. Am J Emerg Med. 2004;22:432-433.https://doi.org/10.1016/j.ajem.2004.06.007