Al-Qadisiyah Journal of Veterinary Medicine Sciences

Poly (lactic-co-glycolic Acid) -loaded Fadrozole preparation by nanoprecipitation method

Document Type : Research Paper

Authors

Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq

10.29079/qjvms.2021.179342

Abstract

Nanoparticles were atoms with smaller than one micron. The size of nanoparticles to 1 to 100 nm, poly (lactic-co-glycolic acid) PLGA had important features including biocompatibility, biodegradability, drug delivery systems (DDS), and constant release. The study assessed the nano-precipitation method of PLGA loaded Fadrozole on induced endometrial periglandular fibrosis (EPF) in female mice compared with the reference Fadrozole. Technology was used to create PLGA nanoparticles, the features of PLGA nanoparticles, included an ultraviolet (UV) spectrophotometer test, which resulted in a PLGA-loaded Fadrozole absorbance (4.5452) with a wavelength of 336.32 nm, as well as other tests included (scanning electron microscope, transmission electron microscope, and zeta potential). According to the description of PLGA revealed in this study, the DMSO associated organic phase alone had specified the form, particle size with a small diameter, charged particles in addition to suitable nanoparticle yield percent, encapsulation efficiency, and drug loading with sufficient stabilizer. Finally, we concluded that female mice who were subjected to artificially induced endometrial periglandular fibrosis by daily 17 – estradiol S/C injection and H2O2 treatment with drinking water for 12 weeks were able to cure with the poly (lactic-co-glycolic acid) -Fadozole regimen therapy at various doses.

 

Keywords

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Al-Qadisiyah Journal of Veterinary Medicine Sciences
Volume 20, Issue 1
May 2021
Pages 46-58
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