Document Type : Review Paper

Author

Scientific and Practical Center of the National Academy of Sciences of Belarus for Biological Resources, Minsk, Belarus

Abstract

Zoonotic protozoan parasites are a diversified group of microscopic eukaryotic organisms that can infect humans and a wide variety of hosts. These fascinating creatures can leap across the species barrier to cause human diseases of global medical and veterinary importance. The study of parasite ecology is essential to understand the mechanisms behind their extraordinary success of crossing species barriers and how they infect and reside within hosts and cause diseases, thus contributing to disease prevention and control infrastructure. Toxoplasma gondii One of the most successful and widespread protozoan parasites is Toxoplasma gondii, which infects virtually all warm-blooded animals including humans. Infection can occur by ingesting infectious forms of these parasites contained in food or water or by exposure to contaminated cat feces. Cryptosporidium Waterborne protozoan parasite causing severe gastrointestinal disease in humans and animals. Giardia Flagellated protozoan parasite, transmitted via the fecal-oral route, by drinking contaminated water or ingesting contaminated food. Entamoeba histolytica Protozoan parasite causing human amebic dysentery and amebic liver abscess.

Keywords

  1. Fayer R. Cryptosporidium: a water-borne zoonotic parasite. Vet Parasitol. 2004;126(1-2):37-56. doi: 10.1016/j.vetpar.2004.09.004, PMID 15567578.
  2. Rohr JR, Dobson AP, Johnson PT, Kilpatrick AM, Paull SH, Raffel TR et al. Frontiers in climate change-disease research. Trends Ecol Evol. 2011;26(6):270-7. doi: 10.1016/j.tree.2011.03.002, PMID 21481487.
  3. Thompson RC. The zoonotic significance and molecular epidemiology of Giardia and giardiasis. Vet Parasitol. 2004;126(1-2):15-35. doi: 10.1016/j.vetpar.2004.09.008, PMID 15567577.
  4. Savioli L, Smith H, Thompson A. Giardia and Cryptosporidium join the ’Neglected Diseases Initiative’. Trends Parasitol. 2006;22(5):203-8. doi: 10.1016/j.pt.2006.02.015, PMID 16545611.
  5. Fayer R, Morgan U, Upton SJ. Epidemiology of Cryptosporidium: transmission, detection and identification. Int J Parasitol. 2000;30(12-13):1305-22. doi: 10.1016/S0020-7519(00)00135-1, PMID 11113257.
  6. Dubey JP. Toxoplasmosis of animals and humans. CRC press; 2010.
  7. Flegr J. Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis. J Exp Biol. 2013;216(1):127-33. doi: 10.1242/jeb.073635, PMID 23225875.
  8. Haque R, Huston CD, Hughes M, Houpt E, Petri WA. Amebiasis. N Engl J Med. 2003;348(16):1565-73. doi: 10.1056/NEJMra022710, PMID 12700377.
  9. Checkley W, White AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for Cryptosporidium. Lancet Infect Dis. 2015;15(1):85-94. doi: 10.1016/S1473-3099(14)70772-8.
  10. Macpherson CN. Human behaviour and the epidemiology of parasitic zoonoses. Int J Parasitol. 2005;35(11-12):1319-31. doi: 10.1016/j.ijpara.2005.06.004, PMID 16102769.
  11. Xiao L, Feng Y. Zoonotic cryptosporidiosis. FEMS Immunol Med Microbiol. 2008;52(3):309-23. doi: 10.1111/j.1574-695X.2008.00377.x, PMID 18205803.
  12. Basco LK. Molecular epidemiology of malaria in Cameroon. XIX. Quality of antimalarial drugs used for self-medication. Am J Trop Med Hyg. 2004;70(3):245-50. doi: 10.4269/ajtmh.2004.70.245, PMID 15031511.
  13. Karanis P, Kourenti C, Smith H. Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt. J Water Health. 2007;5(1):1-38. doi: 10.2166/wh.2006.002, PMID 17402277.
  14. Haque R, Huston CD, Hughes M, Houpt E, Petri WA. Amebiasis. N Engl J Med. 2003;348(16):1565-73. doi: 10.1056/NEJMra022710, PMID 12700377.
  15. Torgerson PR, Keller K, Magnotta M, Ragland N. The global burden of alveolar echinococcosis. PLOS Negl Trop Dis. 2010;4(6):e722. doi: 10.1371/journal.pntd.0000722, PMID 20582310.
  16. Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J et al. Leishmaniasis worldwide and global estimates of its incidence. PLOS ONE. 2012;7(5):e35671. doi: 10.1371/journal.pone.0035671, PMID 22693548.
  17. Rassi Jr A, Rassi A, Marin-Neto JA. Chagas disease. Lancet. 2010;375(9723):1388-402. doi: 10.1016/S0140-6736(10)60061-X.
  18. Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion through control of neglected tropical diseases. Lancet. 2009;373(9674):1570-5. doi: 10.1016/S0140-6736(09)60233-6, PMID 19410718.
  19. Fayer R, Xiao L. Cryptosporidium and cryptosporidiosis. 2nd ed. CRC Press; 2008. doi: 10.1201/9781420052275.
  20. Rabinowitz PM, Conti LA. Human-animal medicine: clinical approaches to zoonoses, toxicants and other shared health risks. Saunders; 2010. doi: 10.1016/B978-1-4160-6837-2.00009-9.
  21. Efstratiou A, Ongerth JE, Karanis P. Waterborne transmission of protozoan parasites: review of worldwide outbreaks-an update 2011-2016. Water Res. 2017;114:14-22. doi: 10.1016/j.watres.2017.01.036, PMID 28214721.
  22. Becker SL, Vogt J, Knopp S, Panning M, Warhurst DC, Polman K et al. Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests. BMC Infect Dis. 2013;13(1):37. doi: 10.1186/1471-2334-13-37, PMID 23347408.
  23. Becker SL, Chatigre JK, Gohou JP, Coulibaly JT, Leuppi R, Polman K et al. Combined stool-based multiplex PCR and microscopy for enhanced pathogen detection in patients with persistent diarrhoea and asymptomatic controls from Côte d’Ivoire. Clin Microbiol Infect. 2015;21(6):591-e1. doi: 10.1016/j.cmi.2015.02.016.
  24. Furst T, Keiser J, Utzinger J. Global burden of human food-borne trematodiasis: A systematic review and meta-analysis. Lancet Infect Dis. 2016;16(3):331-40. doi: 10.1016/s1473-3099(11)70294-8.
  25. Hotez PJ, Alvarado M, Basáñez MG, Bolliger I, Bourne R, Boussinesq M et al. The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases. PLOS Negl Trop Dis. 2014;8(7):e2865. doi: 10.1371/journal.pntd.0002865, PMID 25058013.
  26. Khalil IA, Troeger C, Rao PC, Blacker BF, Brown A, Brewer TG et al. Morbidity, mortality, and long-term consequences of Cryptosporidium infection in children in low-resource settings: a systematic review and meta-analysis. Lancet Glob Health. 2018;6(8):e839-48. doi: 10.1016/S2214-109X(18)30283-3.
  27. Rossle NF, Latif B. Cryptosporidiosis as threatening parasite infection: a review. Asian Pac J Trop Biomed. 2016;6(4):282-8.
  28. Esch KJ, Petersen CA. Transmission and epidemiology of zoonotic protozoal diseases of companion animals. Clin Microbiol Rev. 2013;26(1):58-85. doi: 10.1128/CMR.00067-12, PMID 23297259.
  29. Traub RJ, Monis PT, Robertson I, Irwin P, Mencke N, Thompson RCA. Epidemiological and molecular evidence supports the zoonotic transmission of Giardia among humans and dogs living in the same community. Parasitology. 2004;128(3):253-62. doi: 10.1017/S0031182003004505, PMID 15080083.
  30. Flegr J, Prandota J, Sovičková M, Israili ZH. Toxoplasmosis-a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLOS ONE. 2014;9(3):e90203. doi: 10.1371/journal.pone.0090203, PMID 24662942.
  31. Ortega YR, Sanchez R. Update on Cyclospora cayetanensis, a food-borne and waterborne parasite. Clin Microbiol Rev. 2010;23(1):218-34. doi: 10.1128/CMR.00026-09, PMID 20065331.
  32. Ryan U, Hijjawi N. New developments in Cryptosporidium research. Int J Parasitol. 2015;45(6):367-73. doi: 10.1016/j.ijpara.2015.01.009, PMID 25769247.
  33. Chalmers RM, Katzer F. Looking for Cryptosporidium: the application of advances in detection and diagnosis. Trends Parasitol. 2013;29(5):237-51. doi: 10.1016/j.pt.2013.03.001, PMID 23566713.
  34. Rossignol JF. Cryptosporidium and Giardia: treatment options and prospects for new drugs. Exp Parasitol. 2010;124(1):45-53. doi: 10.1016/j.exppara.2009.07.005, PMID 19632225.
  35. Petersen E. Toxoplasmosis. Semin Fetal Neonatal Med. 2007;12(3):214-23. doi: 10.1016/j.siny.2007.01.011, PMID 17321812.